Abstract：The purpose of this study was to investigate the effect of in-line skating around Taiwan on the levels of plasma ghrelin and leptin in young adults. Nine male amateur college athletes (average age: 20.8 ± 2.2 yrs; BMI: 21.6 ± 2.0 kg/m^2; VO_2max = 54.5 ± 5.9 mL/kg/min) were engaged in a 7-day exercise activity of in-line skating around Taiwan (total distance = 953 km). The levels of plasma ghrelin and leptin were measured on the 1st, 4th and 7th day before and/or after exercise. The detailed time intervals for blood collection were before exercise/ immediately after exercise on the 1st day, before exercise on the 4th day, before/immediately after exercise on the 7th day, 36 hours after all exercise, and 10 days after the exercise. The results indicated that plasma ghrelin level was significantly increased from 921.5 ± 185.1 pg/ml to 1,127.8 ± 220.6 pg/ml after exercise of seven consecutive days, and recovered to resting level after 36 hours rest following exercise. On the other hand, plasma leptin level was decreased from 1.1 ± 0.2 ng/ml to 0.5 ± 0.2 ng/ml, and gradually returned to baseline after 36-hour rest. These results conclude that under the stable condition of body composition, plasma ghrelin level was significantly increased, while plasma leptin level was significantly decreased after 7 days of in-line skating around Taiwan. Both ghrelin and leptin levels were returned to baseline after 36-hour rest following skating. This study suggests that short-term endurance exercise could be an independent factor to influence the plasma leptin and ghrelin levels in young adults. (Full text)