Abstract：Purpose: This study was aimed to examine the interactive effects of hypoxia plus exercise training on obese level, serum leptin and glucose uptake in obese and lean Zucker rats. Methods: Sixty-four Zucker rats both lean (n=32) and obese (n=32) were divided into 8 groups such as, lean control (LC, n=8), lean hypoxia (LH, n=8), lean exercise (LE, n=8), lean hypoxia + exercise (LHE, n=8), obese control (OC, n=8), obese hypoxia (OH, n=8), obese exercise (OE, n=8) and obese hypoxia + exercise (OHE, n=8). In all groups food intake, bodyweight, fat mass, serum leptin and glucose uptake were measured after the treatment. Results: The food intake was higher in obese control group and this was significantly decreased with hypoxia plus exercise treatment which is similar to the LHE group. We observed reduces bodyweight only in obese exercised group, however, hypoxia with exercise resulted in both lean and obese groups. Exercise also reduces the fat mass in both lean and obese groups whereas, no change with interaction of hypoxia plus exercise treatment. Serum leptin levels were significantly decreased with exercise and also with hypoxia plus exercise treatments. Glucose uptake was improved with hypoxia plus exercise treatment in both lean and obese groups. Conclusion: These results indicate that hypoxia with exercise training considered as more effective on reducing fat mass and improving glucose uptake. This data suggest that interactive treatment may be a suitable strategy to control the obese degree and blood glucose level in obese population. (Full text)