Abstract：The purpose of this study was to use the somatosensory video games on simple reaction of the institutionalized older adults. All participants above 65 years old were non-randomly assigned into experimental or control groups. The cognitive abilities were controlled as the confounding variables by the mini-mental state examination (MMSE). The participants were recruited and divided into four groups, including 4-week experimental group with mild cognitive impairment (MCI; n=9; MMSE=20.44±1.67), 8-week experimental group with no cognitive impairment (NCI; n=8; MMSE=28.25±2.43), 4-week control group with MCI (n=9; MMSE=21.22±1.79) and 8-week control group with NCI (n=9; MMSE=26.44±2.46). The experimental group completed 30-minute Xbox games 3 times per week. Non-parametric statistical analysis was used to compare the differences between and within the groups. The results showed that the mean reaction time and measure of dispersion reaction time were not significantly different between 4-week experimental group with MCI and 4-week control group with MCI. However, 8-week experimental group with NCI had significantly difference on simple reaction compared to 8-week control group with NCI, and showed that measure of dispersion reaction time had significantly regress after the withdrawal. These results conclude that somatosensory video game may have the positive effects on simple reaction in institutionalized older adults. Although the elders may not have immediately improvements on the neurons speed, the effect can restrain the deterioration of the simple reaction from the aging. (Full text)